Combine the mayonnaise, sweet relish, mustard, vinegar, garlic powder, onion powder, paprika, and sugar in a small mixing bowl.
Stir thoroughly until the mixture is creamy and homogeneous.
Adjust flavor balance as desired by increasing the relish for added sweetness or the mustard for extra tanginess.
For optimal taste, transfer the sauce to the refrigerator and chill for 30 minutes to allow the flavors to integrate fully.
Keep any extra spread in a sealed container in the refrigerator and use within 7 days.