Rinse the pork butt thoroughly under cool water and blot it dry using paper towels. Set the meat into the insert of a slow cooker.
Sprinkle the coarse salt over the surface of the pork, ensuring even coverage. Drizzle the liquid smoke directly atop the meat to enhance its depth of flavor.
Secure the lid and set the slow cooker to the Low setting. Allow the pork to cook undisturbed for a minimum of 12 hours, preferably up to 16 hours, and as long as 20 hours for optimal tenderness. Do not introduce any additional liquid during this time.
Once the pork has reached a fall-apart texture, use two forks to shred the meat directly in the slow cooker. Combine thoroughly with the rendered juices before serving.